The technological progress has brought us many new discoveries and better facilities, but it has also changed our daily lives. Recently, with the rapid development of augmented reality and virtual reality techniques, there has been a lot of business opportunities through the perception of context to make human senses have new experiences. The mixed reality device such as Microsoft HoloLens can detect the 3D environment and respond to the user via voice instructions. This technology can be applied to blind people for more convenience in their daily moves. In this paper, we have implemented a blind indoor navigation system using Microsoft HoloLens. With the proposed system, we can get the camera's coordinates and direction and detect distance from obstacles via the HoloLens functions such as gaze detection, image recognition, audio recognition and output. This system can also provide various blind guidance functions such as planning of safety paths, display the name of near targets, and BB sound warnings when walking beyond the safe path range. The system mainly controls the activities and functions through voice commands. To evaluate the system performance, we invited 8 testers to use the indoor navigation system to guide users through voice commands. After the experiments, the testers filled in the scores and opinions of a questionnaire. The experimental results show that the proposed system has good performance and provides a potential indoor navigation application for the visually impaired.